SPOF Full Form. Full Meaning of SPOF Find long form and abbreviation, slang or definition of SPOF. What does SPOF mean? What does SPOF stand for? We are providing world largest and most comprehensive acronyms, names, abbreviations database directory on the Internet. Our data base contains more than 8,00,000 terms abbreviations and acronyms. You can also search unique terms more than 4,00,000 general Comprehensive words.